NAD+
- Ex Tax: $252.99
- Product Code: M00000012
- Availability: In Stock
CharacteristicsMolecular FormulaC21H27N7O14P2CAS53-84-9Molar Mass663.43 g/molSynonymsDiphosphopyridine nucleotide, Nadide, Coenzyme 1, DPNSolubilitySoluble in WaterOrganoleptic ProfileWhite powderCompositionLyophilized powder - requires reconstitutionHow does NAD+ work?NAD+ acts as a critical coenzy..
Available Options
Characteristics
Molecular Formula | C21H27N7O14P2 |
CAS | 53-84-9 |
Molar Mass | 663.43 g/mol |
Synonyms | Diphosphopyridine nucleotide, Nadide, Coenzyme 1, DPN |
Solubility | Soluble in Water |
Organoleptic Profile | White powder |
Composition | Lyophilized powder - requires reconstitution |
How does NAD+ work?
NAD+ acts as a critical coenzyme in redox reactions, accepting or donating electrons in metabolic pathways such as glycolysis, fatty acid oxidation, and the citric acid cycle. It is a substrate for sirtuins, NAD+-dependent deacetylases that remove acetyl groups from proteins and regulate gene expression. Sirtuins are involved in DNA repair, stress resistance, inflammation, and metabolic homeostasis, which helps explain several observed NAD+ benefits.
NAD+ is also consumed by poly(ADP-ribose) polymerases (PARPs) in response to DNA damage. PARPs help repair DNA but can deplete NAD+ levels if overactivated. CD38, an enzyme that generates cyclic ADP-ribose, also consumes NAD+.
NAD+ can be synthesized de novo from the amino acid tryptophan or through salvage pathways using precursors like nicotinic acid, nicotinamide, and nicotinamide riboside. Supplementing with these precursors can boost NAD+ levels.
Summary
NAD+ is a vital coenzyme involved in energy metabolism, DNA repair, cell signaling, and aging. NAD+ levels can be supported either directly through NAD+ injection or indirectly through NAD+ supplements that contain precursors used by the body to synthesize NAD+. Maintaining optimal NAD+ levels through supplementation with precursors or other means may provide benefits for longevity, metabolic health, cardiovascular health, neurological function, DNA repair, and inflammation. While NAD+ precursors are generally safe, it is important to use them under medical supervision and be aware of potential side effects at high doses.