ARA-290

Characteristics

How does ARA-290 work?

ARA-290 exerts its effects by selectively activating the innate repair receptor (IRR), a heteromeric complex composed of EPO receptor (EPOR) and β common receptor (βcR) subunits. This specific interaction triggers a cascade of signaling events that lead to anti-inflammatory, tissue-protective, and repair-promoting effects. ARA-290 has been shown to modulate the immune response by reducing the production of pro-inflammatory cytokines and increasing the expression of anti-inflammatory mediators. Additionally, it promotes the survival and function of various cell types, including endothelial cells, cardiomyocytes, and neurons, under stress conditions.

Preparation

ARA-290 Experimental Reagent: Preparation GuidelinesImportant: Please read these instructions carefully before handling the ARA-290 experimental reagent.

Dissolution:

• Due to the high density of ARA-290, dissolve 12mg of the reagent in a minimum of 3ml of bacteriostatic water (BAC water).

Preparation Steps:

1. Remove the experimental reagent from storage and allow it to reach room temperature (approximately 2-3 hours).

2. Once at room temperature, add the appropriate amount of BAC water.

3. After reconstitution, keep the solution at room temperature. Do not refrigerate or refreeze.

Caution:

• Reconstituting or storing the reagent in low-temperature environments may cause cloudiness.

• Avoid exposing the reconstituted solution to cold temperatures to maintain its clarity and effectiveness.

For optimal results, please follow these guidelines closely.

Summary

ARA 290 peptide is a promising synthetic peptide that mimics the tissue-protective and repair-promoting properties of EPO without stimulating erythropoiesis. By selectively activating the innate repair receptor, ARA-290 exerts potent anti-inflammatory, neuroprotective, cardioprotective, and renoprotective effects in various preclinical models. Clinical studies have also demonstrated its potential in tissue-protective effects and wound research. With its favorable safety profile and wide-ranging therapeutic potential, ARA-290 represents an exciting avenue for the development of novel treatments for a variety of conditions characterized by tissue damage and inflammation.

For laboratories searching for ara 290 for sale or looking to buy ara 290, sourcing from a reputable research-grade supplier with verified purity and analytical validation is essential to ensure experimental accuracy.

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